Molecular Determinants of Seminal Plasma on Sperm Biology and Fertility

Components of fractionated stallion seminal plasma and the effects of seminal plasma on sperm longevity

.................................................................................................................................................. 7 List of original publications ..................................................................................................................... 9 Abbreviations .......................................................................................

Reactive Oxygen Species and Antioxidant in Seminal Plasma and Their Impact on Male Fertility

Spermatozoa generate reactive oxygen species (ROS) in physiological amounts which play a role in sperm functions during sperm capacitation acrosome reaction (AR) and oocyte fusion. In addition damaged sperm are likely to be the source of ROS. The most important ROS produced by human sperm are hydrogen peroxide superoxide anion and hydroxyl radicals. Besides human seminal plasma and sperm posses...

Biomarkers of in vivo fertility in sperm and seminal plasma of fertile stallions.

The global proteome of sperm and seminal plasma of fertile stallions was investigated to determine whether associations with relative in vivo fertility exist. Seven stallions at stud in a commercial breeding station were collected throughout the breeding season and bred to a total of 164 mares to determine conception rates. On three occasions during the breeding season, raw semen was obtained f...

Increased seminal plasma lead levels adversely affect the fertility potential of sperm in IVF.

BACKGROUND Lead remains in high levels in the environment and is known to reduce fertility in animal models, but a direct link between lead exposures and human infertility has not yet been established. METHODS In a prospective, double-blind study of the metal ion levels and sperm function, semen was obtained from partners of 140 consecutive women undergoing their first IVF cycle. Lead in semi...

mRNA profiling for the identification of sperm and seminal plasma